Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions
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چکیده
منابع مشابه
Flt3-ligand treatment prevents diabetes in NOD mice.
The mechanism by which mixed chimerism reverses autoimmunity in type 1 diabetes has not been defined. NOD mice have a well-characterized defect in the production of myeloid progenitors that is believed to contribute significantly to the autoimmune process. We therefore investigated whether chimerism induces a correction of this defect. Mixed chimerism restored production of myeloid progenitors ...
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Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2004
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200425141